Two neuroprotective type inhibitors of FTO were synthesized through the computational method and were used and analyzed through an artificial BBB, concluding that it could become a therapeutic strategy in curing AD, PD, etc.259Although FTO's role in neuroinflammation or neurodegeneration has not been confirmed yet, it has a part in the development and functionality of the brain,196 and it has been associated with various kinds of neurological disorders like PD, AD, epilepsy, and even depression, and anxiety.196. Here, FTO is linked to major depressive disorder.