Prenylated quinoline carboxylic acid derivatives prevent neuronal cell death by inhibiting MKK4;52 Inhibition of S‐nitrosation of MKK4 protects the hippocampal CA1 neurons in cerebral ischemia/reperfusion of rats;53, 54 MKK4 has also been identified as a key regulatory factor for liver regeneration.55 This evidence concerns the gene MAP2K4 and Cerebral ischemia.