Then KEGG analysis showed that the signaling pathways of PNS and aging mainly involved pathways in cancer, proteoglycans in cancer, eGFR tyrosine kinase inhibitor resistance, neurotrophin signaling pathway, apoptosis, chemical carcinogenesis‐receptor activation, PI3K‐Akt signaling pathway, Ras signaling pathway, Rapl signaling pathway, and Alzheimer disease. Here, RASSF5 is linked to early-onset autosomal dominant Alzheimer disease.