Microglia are also highly expressed in TREM1 upon activation,64, 65 which can mediate neuroinflammation in ischemic stroke by interacting with the spleen tyrosine kinase (SYK) signaling pathway, activating downstream NF‐κB and nucleotide‐binding oligomerization domain (NLRP3) inflammasomes. This evidence concerns the gene SYK and ischemic stroke.