CuP/Er not only increase tumor cell sensitivity to cuproptosis, but also induces strong immunogenic cell death, enhances antigen presentation, and upregulates PD-L1 expression, thereby synergizing with anti-PD-L1 antibodies to effectively mediate regression of colon adenocarcinoma in mice (Li Y. et al., 2024).In conclusion, the advancement of therapeutic strategies targeting multiple cell death pathways will help overcome cancer cell resistance. Here, CD274 is linked to colon adenocarcinoma.