CD44 and cancer: Additionally, the utilization of biomimetic cell membranes for NP surface modification can enhance ligand binding and increase tumor cell uptake efficiency, achieving homologous tumor targeting (Fang et al., 2014).Furthermore, platelet membrane-coated NPs can be targeted by p-selectin on cell membranes to bind CD44 overexpressed in cancer cells, thus improving cancer cell targeting (Hu et al., 2015).