Recent research led by Fang et al. developed an injectable zwitterionic hydrogel system (Gel@M/CuO2/DOX/STING) loaded with nanoparticles (M/CuO2/DOX) and STING agonists 2′,3′-cGAMP, demonstrating a superior ability to specifically target and eradicate tumor cells while reshaping TMEs. The gene discussed is STING1; the disease is neoplasm.