CD8A and colorectal cancer: For example, Zeng et al. found that cuproptosis in microsatellite-stabilized colorectal cancer cells can enhance the cytotoxicity of CD8+ T cells by downregulating the WNT signaling pathway (Zeng et al., 2024).In tumor cells, cuproptosis also can improve anti-tumor immune responses through cGAS-STING signaling.