Zheng et al. reported that DSF/Cu co-delivery system can trigger tumor cell autophagy and induce immunogenic cell death, promote M1 macrophage polarization and dendritic cell maturation, and enhance the killing effect of CD8+ T cells and NK cells, thereby promoting anti-tumor immune response and tumor regression (Zheng et al., 2020). The gene discussed is CD8A; the disease is neoplasm.