In the PS-adjusted analysis using IPTW, the following variables were considered: age, sex, HbA1c, serum albumin, hemoglobin, total cholesterol, triglycerides, LDL-cholesterol (LDL-c), eGFR, eGFR stratification, hypertension, hematuria, proteinuria classification, insulin, oral hypoglycemic drugs, Angiotension Converting Enzyme inhibitors (ACEi), Angiotensin Receptor Blocker (ARB), statins, and the pre-treatment eGFR decline slope. The gene discussed is INS; the disease is Hypertension.