Paravati’s study suggests that IFN-γ activates the Nuclear Factor Kappa-B (NF-κB) and Signal Transducer and Activator of Transcription 1 (STAT1) signaling pathways, resulting in abnormal expression of osteopontin and Cluster of Differentiation 44 (CD44) in the endometrium, which compromises endometrial receptivity and exacerbates reproductive dysfunction in PCOS (32). This evidence concerns the gene NFKB1 and polycystic ovary syndrome.