Paravati’s study suggests that IFN-γ activates the Nuclear Factor Kappa-B (NF-κB) and Signal Transducer and Activator of Transcription 1 (STAT1) signaling pathways, resulting in abnormal expression of osteopontin and Cluster of Differentiation 44 (CD44) in the endometrium, which compromises endometrial receptivity and exacerbates reproductive dysfunction in PCOS (32). Here, STAT1 is linked to polycystic ovary syndrome.