SPP1 and polycystic ovary syndrome: Paravati’s study suggests that IFN-γ activates the Nuclear Factor Kappa-B (NF-κB) and Signal Transducer and Activator of Transcription 1 (STAT1) signaling pathways, resulting in abnormal expression of osteopontin and Cluster of Differentiation 44 (CD44) in the endometrium, which compromises endometrial receptivity and exacerbates reproductive dysfunction in PCOS (32).