Recent genome-wide association studies (GWAS) and exome sequencing have identified multiple genetic variants associated with AD risk, such as rare variants in genes like NOTCH3, TREM2, SORL1, ABCA7, ATP8B4, and ABCA1 (Khani et al., 2022; Bellenguez et al., 2022; Holstege et al., 2022). The gene discussed is TREM2; the disease is Alzheimer disease.