Emerging pieces of evidence indicate that the ITGAV gene leads to the development and progression of various malignancies, such as colon carcinoma, pancreatic adenocarcinoma, esophageal adenocarcinoma, gastric cancer, hepatocellular carcinoma [51, 52, 53, 54, 55, 56]. Here, ITGAV is linked to esophageal adenocarcinoma.