These results suggest that NPC2 and ITGAV may be useful as novel pathological staging markers for LIHC, PAAD, and STAD; nevertheless, it would be noteworthy to elucidate further the mechanism by which NPC2 and ITGAV are only linked with LIHC, PAAD, and STAD prognosis or pathological staging. Here, NPC2 is linked to gastric adenocarcinoma.