In contrast, Nur77 knockout is reported to augment cardiac fibrosis after myocardial infarction, where the deficiency of Nur77 enhanced endothelial‐to‐mesenchymal transition (EndMT) that is evident by the increased expression of FSP‐1, SM22α, and Snail (EndMT) and the decreased expression of Platelet endothelial cell adhesion molecule‐1 (PECAM‐1) (endothelial marker) and Endothelial nitric oxide synthase (eNOS).156. This evidence concerns the gene NOS3 and myocardial infarction.