α‐Myosin heavy chain (α‐MHC), β‐MHC, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP), the main hypertrophic markers known to be associated with cardiac hypertrophy and fibrosis, were significantly induced by ISP treatment.63, 141. The gene discussed is NPPB; the disease is cardiac hypertrophy.