Moreover, ISP was observed to upregulate the expression of liver kinase B1 interacting protein 1 (LKB1IP), which positively promotes ISP‐induced cardiac hypertrophy through activating AKT signaling by directly targeting and interacting with PTEN (a negative regulator of AKT phosphorylation) and inhibiting its phosphatase activity. Here, AKT1 is linked to cardiac hypertrophy.