The S1PR2 receptor was originally found to be involved in hepatic lipid metabolism204 and liver disease.205–208 Conjugated bile acids activate the ERK1/2 and AKT signaling pathways primarily through S1PR2.204,209 In addition to bile acids, another important ligand of S1PR2 is sphingosine-1-phosphate (S1P). The gene discussed is S1PR2; the disease is liver disorder.