BDNF and early-onset autosomal dominant Alzheimer disease: To delve deeper into reality, short social interactions between the PAM and NPAM may underly the observed improvements in health.94 Furthermore, physical contact appears to be crucial to experiencing the positive effects of social interaction.95 In addition, studies have suggested that social interaction rescues memory deficits in animal models of Alzheimer’s disease by increasing brain-derived neurotrophic factor (BDNF)-dependent hippocampal neurogenesis.96