The significant reduction in NLRP3, ASC, pro-caspase-1, and IL-1β levels in the Model+shTXNIP group (P < 0.05, Figure 6A–6F) highlights the protective effect of TXNIP knockdown in alleviating neuroinflammation and underscores its potential as a therapeutic target for mitigating ischemic stroke-induced brain injury. This evidence concerns the gene CASP1 and ischemic stroke.