A recent study conducted genetic and functional analyses of inflammasomes and identified rare homogeneous variants of NLRP1 (p.Ile601Phe and p.Ser1387Ile), a variant of NLRP3 (p.Leu832Ile), which substitutes an amino acid in a crucial leucine‐repeat domain, as well as variants of NLRC4 (p.Arg310Ter and p.Glu600Ter), leading to protein truncation in some MS patients. Here, NLRP1 is linked to myeloid sarcoma.