Additional in vitro investigations revealed that resveratrol treatment led to upregulation of PD-L1 expression across various tumorigenic cell lines such as BT549, SKBR3, and Cal51 breast cancer cells, BT474 invasive ductal carcinoma, and HCT116, SW480, and SW620 colon cancer cells [234]. This evidence concerns the gene CD274 and malignant colon neoplasm.