Conversely, intracellular glutamate concentrations were halved in NRF2-high cells compared to NRF2-low cells (2.0 ± 0.42 nmol/mg protein vs 3.9 ± 1.1 nmol/mg protein, respectively; n = 4 cell lines per group; p = 0.02; Fig. 1d), providing evidence that not only xCT expression but transporter activity were increased in NRF2-high NSCLC cells. This evidence concerns the gene SLC7A11 and non-small cell lung carcinoma.