The elevated antioxidant capacity of NRF2-mutant xenografts was reflected in a doubling of GSH in these tumours (0.90 ± 0.46 nmol/mg protein for CRUK0772 R1 compared to 0.43 ± 0.12 nmol/mg protein for CRUK0640 R8; n = 4 tumours/group; p = 0.047; Fig. 5f), again recapitulating the pattern of [18F]FSPG retention. This evidence concerns the gene NFE2L2 and neoplasm.