The serum level of lncRNA CASC2 was significantly increased in non-LN patients, showing a median (IQR) fold change of 3.21 (2.07–5.7) (P < 0.001) versus the healthy control group, and a higher value of 7.89 (1.87–10.33) (p < 0.01) was observed among the LN group relative to both the non-LN (p < 0.01) and control groups (p < 0.01). Here, CASC2 is linked to lobular neoplasia.