In LN patients, lncRNA CASC2 had significant positive correlation to anti-dsDNA (r = 0.56, p = 0.001), proteinuria (r = 0.54, p = 0.002) and SLEDAI (r = 0.5, p = 0.003), while miR-155 showed a significant negative correlation with SCr (r = − 0.37, p = 0.04) and SLEDAI (r = − 0.53, p = 0.003). The gene discussed is CASC2; the disease is lobular neoplasia.