To further elucidate HMGA1's impact on ESCC susceptibility to olaparib, we used shRNA to knock down HMGA1 in KYSE510 cells, exposed the cells to olaparib, and measured the IC50 (the concentration at which 50% of cells cease proliferating) of the cells. This evidence concerns the gene HMGA1 and esophageal squamous cell carcinoma.