TKT and cancer: If a relationship exists between the multi-protein complex target of PAV-951 (which includes several context-dependent metastasis-implicated proteins such as ALDH, CAP1, GSTP1, HSP90, PDI, TKT and VCL, see electronic supplementary material, figure S8) and progression to metastasis, further studies conducted under trypsinized conditions may be provide insights on the relationship between protein assembly and EMT as it relates to the hallmarks of cancer [33,41,45–63].