Cisplatin injection coupled with high dietary phosphate induced CKD disturbs mineral metabolism mimicking human CKD.40 The expected increase in renal lymphatic density was verified by LYVE-1 immunolabelling and was significantly higher in the kidneys of KidVD+ mice compared with their injured KidVD− littermates after disease progression (Figure 3, B and C). The gene discussed is LYVE1; the disease is chronic kidney disease.