CKD progression is accompanied with a parallel increase in renal lymphatic vessel density,25, –27 through increased production of lymphangiogenic ligand VEGF-D, which is often implicated in inflammation, in AA and POD mice.62, , –65 A review of several studies highlights a positive correlation between fibrosis and lymphangiogenesis,66 with one study demonstrating that renal tubular activated fibroblast preferentially increase lymphatic endothelial cell proliferation over the blood endothelial cells.67 Whether fibrosis drives lymphangiogenesis or vice versa is unclear. The gene discussed is VEGFD; the disease is chronic kidney disease.