However, in melanoma cell lines LB2259-MEL and CP50-MEL treated with IL-1β, IL-1β might reduce the expression of MITF through the NF-κB and JNK pathways, and this reduction is associated with the expression of the IL-1 receptor type I (IL-1RI) gene in melanoma cells [97, 98]. This evidence concerns the gene MAPK8 and melanoma.