A previous study evaluating plasma protein changes in APOE4 subjects identified unique “dementia‐associated proteins.”66 While only two of the six proteins identified were measured in our study, both proteins, IGFBP2 and F10, were not significant in our evaluation of APOE4‐associated plasma proteins in our cohort of elderly subjects without dementia, perhaps arguing that differences might be related to disease stage. The gene discussed is IGFBP2; the disease is dementia.