To evaluate whether plasma proteomic pathways are dysregulated according to APOE4 status, we submitted differentially abundant plasma proteins to Ingenuity Pathway Analysis (IPA), revealing several significant pathways (FDR < 0.05) associated with immune function, including “STAT3” and “IL‐15 production”, as well as predicted changes in “atherosclerosis” pathways (Fig. S2A). This evidence concerns the gene APOE and atherosclerosis.