TWEAK, the ligand of TNFRSF12A, has previously been reported to be involved in lupus pathology (52), and LIGHT (TNFSF14), a ligand of HVEM (TNFRSF14), is commonly dysregulated in murine lupus (53, 54). This evidence concerns the gene TNFRSF12A and systemic lupus erythematosus.