LRRK2 and Parkinson disease: These proteins were selected based on their genetic link to PD, their presence in Lewy bodies, and/or their being implicated in preclinical models of PD: PINK1 (4, 22, 23, 28, 29), parkin (5, 22, 23), OGDH (22, 30), GBA (6, 8, 31), SOD1 (25, 32), and LRRK2 (7, 29) (Figure 1A).