Here, we tested whether OGDH and other proteins involved in the PD disease process (i.e., PINK1, PARKIN, GBA, SOD1, LRRK2) may elicit T cell responses from individuals with PD and identified the mitochondria-associated protein PINK1 as an autoantigen recognized by T cells from PD patients. The gene discussed is GBA1; the disease is Parkinson disease.