These proteins were selected based on their genetic link to PD, their presence in Lewy bodies, and/or their being implicated in preclinical models of PD: PINK1 (4, 22, 23, 28, 29), parkin (5, 22, 23), OGDH (22, 30), GBA (6, 8, 31), SOD1 (25, 32), and LRRK2 (7, 29) (Figure 1A). The gene discussed is PRKN; the disease is Parkinson disease.