LRRK2 and Parkinson disease: Similarly, LRRK2 responses had more male PD patients than male HCs responding to it, albeit with no significant difference in magnitude of response (6.0-fold, Mann-Whitney U test, P = 0.07; Fisher’s exact test, P = 0.036) versus females (0.8-fold difference in PD versus HCs; Mann-Whitney U test, P = 0.95; Fisher’s exact test, P = 1.0).