The T cell reactivity to the neuroantigen pools is shown in Figure 1B. A significant increase in the frequency (the number of samples that responded versus those that did not respond to the peptide pools) of PINK1 reactivity was observed among PD patients compared with HCs, although the magnitude of the PINK1 response was not significantly increased (1.8-fold increase, Fisher’s exact 2-tailed test, P = 0.049; 2-tailed Mann-Whitney, P = 0.063). This evidence concerns the gene PINK1 and Parkinson disease.