NEDD4L and neoplasm: As shown in Figure 9, I–L, DFOM treatment significantly inhibited AOM/DSS–induced tumor formation and lipid peroxidation in Nedd4lfl/fl VillinCre mice compared with the ddH2O-treated control mice, and further eliminated the phenotype difference between Nedd4lfl/fl VillinCre mice and Nedd4lfl/fl mice, suggesting that NEDD4L regulated CAC through ferroptosis signaling.