Although Syk is known to be a target for NEDD4L in mast cells (41), continual intraperitoneal (i.p.)injection of a Syk-specific inhibitor, BAY 61-3606, during colitis induction did not eliminate the colitis phenotype difference between Nedd4lfl/fl VillinCre and Nedd4lfl/fl mice (Supplemental Figure 9, G–J). Here, NEDD4L is linked to colitis.