NEDD4L and colitis: To further explore whether the protective role of NEDD4L in colitis was intrinsic to IECs, we generated mice with IEC-specific KO of Nedd4l (Nedd4lfl/fl VillinCre) by crossing Nedd4l-floxed mice (Nedd4lfl/fl) with VillinCre mice, resulting in constitutive deletion of Nedd4l in the IECs.