Compared with their WT littermates, we found higher levels of Ki67+ cells per crypt in the adjacent tumor and tumor tissues from Nedd4l+/– and Nedd4lfl/fl VillinCre mice following AOM/DSS treatment (Figure 9, E and F, and Supplemental Figure 12, D and E), as well as increased lipid peroxidation production in tumor tissues of Nedd4lfl/fl VillinCre mice (Figure 9G). Here, NEDD4L is linked to infectious otitis media.