MUC5AC and colitis: However, an abnormally increased abundance of Akkermansia could promote the degradation of intestinal mucin, thus exacerbating colitis in mice (42), which is consistent with our phenotype that Nedd4lfl/fl VillinCre mice exhibited less intestinal mucin production after DSS treatment visualized by AB-PAS staining of the colon sections (Supplemental Figure 11H).