GO analysis showed that cell-intrinsic apoptotic signaling and regulation of the hydrogen peroxide metabolic process were significantly upregulated in colonic tissues from Nedd4lfl/fl VillinCre mice compared with Nedd4lfl/fl mice (Supplemental Figure 9B), suggesting that cell death and peroxidation may be involved in NEDD4L-mediated colitis. This evidence concerns the gene NEDD4L and colitis.