While it is possible that reduced PTH underlies the FGF23 reduction observed in VillinCreERT2Cyp24fl/fl mice with kidney damage, PTH was also reduced in VillinCreERT2Cyp24fl/fl mice with intact kidneys in response to a high calcium diet, yet FGF23 was modestly but significantly increased in that setting. The gene discussed is PTH; the disease is Nephropathy.