However, several factors (such as post‐translational modifications and mutations) can decrease tau's affinity for the microtubules and/or induce tau misfolding, thereby increasing its propensity to aggregate, leading to the formation of oligomers and their subsequent aggregation into insoluble fibrils.[2, 3] The accumulation of these fibrils results in the formation of intracellular neurofibrillary tangles (NFTs), which are one of the pathological hallmarks of a group of diseases known as tauopathies. Here, MAPT is linked to Neurofibrillary tangles.