Mutations affecting exon 10 splicing have been implicated in familial tauopathies such as PSP, CBD, and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP‐17).[38, 39] The tau protein comprises the N‐terminal projection domain, a proline‐rich region, and a microtubule‐binding repeat (MTBR) region (Scheme 2B). Here, MAPT is linked to supranuclear palsy, progressive, 1.