KCNMA1 and infection: To test if the CovSAla318Val mutation, which results in increased SLO expression, might induce amplified inflammasome activation, human macrophage-like THP-1 cells were infected with SF370 (M1), 5448 (M1global), SP1380 (M1UK), and SP1450 (see Fig. 1) at a multiplicity of infection (MOI) of 25.