POMC and gonorrhea: For instance, GN‐PAs (especially in elderly patients) are typically noninvasive, whereas sparsely granulated GH‐PAs, Crooke cell adenomas, silent ACTH‐PAs, PRL‐PAs occurring in males, and pituitary‐specific transcription factor 1 (Pit‐1) positive PAs secreting multiple hormones tend to be invasive.