Obviously, our data do not exclude that SORLA may impact other microglial functions not tested here, such as migration under guided conditions, as observed for TREM2‐dependent migration towards senile plaques (McQuade et al. 2020), or that (amyloid) particles used for uptake studies may have impacted our results as compared to a previous report (Liu et al. 2020). Here, TREM2 is linked to Senile plaques.