ThePIK-75 oc-HDL NPs specifically target SR-B1, which has beenshown to be expressed in both CTCL, PCa, and numerous other malignantcell types in vitro and in vivo.(13,16,19,20,22,34,40−43) Targeted delivery of PIK-75 potentlyinduced cell death in CTCL and prostate cancer cell lines, as wellas in the NCI-60 panel and 6 additional pancreatic cancer cell lineswhile having minimal effect on normal SR-B1+ cells (e.g.,macrophages and hepatocytes). Here, SCARB1 is linked to familial pancreatic carcinoma.