PRKDC and posterior cortical atrophy: These data reinforce thefindings that PIK-75 is an effective therapeutic against several differentmalignancies, due to its ability to inhibit critical kinases (e.g.,p110α, DNA-PK, p38γ) across a range of signaling pathways.Systemic administration of PIK-75 oc-HDL NPs significantly reducedthe growth of PCa xenografts.