Abnormally activated NFATC4 has been reported to be involved in and regulate the initiation, proliferation, invasion, and metastasis of a variety of cancers, including lung, breast, ovarian, cervical, skin, liver, and pancreatic cancers, as well as glioma, primary myelofibrosis, and acute myeloid leukemia (37), and it is worth further investigating whether PLEK2 exerts a pro-carcinogenic effect by regulating NFATC4. Here, NFATC4 is linked to familial pancreatic carcinoma.