The most common treatment-related AEs were mainly gastrointestinal reactions and skin adverse reactions, including fatigue, diarrhea, pruritus, nausea, pyrexia, abdominal pain, decreased appetite, bowel obstruction, hyperthyroidism, increased ALT, increased AST, thrombocytopenia, pneumonia, and neutropenia. This evidence concerns the gene GPT and Thrombocytopenia.