Regorafenib, a novel oral multi-kinase inhibitor, disrupts kinases involved in tumor angiogenesis (VEGFR1, VEGFR2, VEGFR3, TIE2), tumorigenesis (KIT, RET, RAF1, BRAF, and BRAFV600E), and the tumor microenvironment (PDGFR and FGFR) (9). This evidence concerns the gene TEK and neoplasm.