GPT and obesity due to melanocortin 4 receptor deficiency: This mechanism could similarly help explain a possible link between the AST/ALT ratio and lung adenocarcinoma, as lung adenocarcinoma may exhibit a stronger correlation with these factors compared to other types of lung cancer.Furthermore, Sofia Christakoudi (41) reported a negative correlation between ALT levels and lung cancer risk in men, suggesting that elevated ALT might be linked to obesity-related non-alcoholic fatty liver disease (NAFLD) and liver fibrosis, conditions that can reduce platelet counts and potentially lower lung cancer risk.