It was found that the concentration of p65 (the transcription factor of the NF-kB pathway) was found to be reduced in TNF-α-stimulated skin cancer cells (232.89 pg/ml), colon cancer cells (325.89 pg/ml), unstimulated skin cancer cells (63.16 pg/ml), and colon cancer cell lines (88.13 pg/ml) as compared with control cultures by the AML extract. Here, RELA is linked to skin cancer.