The mir-26a-IL-6-IL-17 axis attenuated NAFLD through inhibition of IL-6 in a murine model of high-fat diet-induced obesity. IL-17 neutralization markedly decreased total liver weight, hepatic triglyceride deposition, and serum ALT concentration when compared with the control group. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.