In the AKI model induced by pesticides, the inhibition of ferroptosis can alleviate the activation of the NLRP3 inflammasome (Zhang et al., 2023); in the acute lung injury model caused by sepsis, NLRP3 interacts with ferroptosis (Cao et al., 2022); in the macrophage model induced by PM, it was discovered that NLRP3 inflammasome inhibitors had an inhibitory effect on the increase in intracellular free iron levels and the expression of iron-related proteins. Here, NLRP3 is linked to Sepsis.