Consistent with the idea that CMA might have a tumor-suppressor function, three types of long-lived mice with elevated CMA (Snell dwarf, ghr KO, and PTEN overexpressor) all have reduced frequencies of spontaneous cancers (Ortega-Molina et al., 2012; Anisimov and Bartke, 2013). The gene discussed is GHR; the disease is cancer.