PTEN and fatty liver disease: Mice with a liver-specific Pten deletion [PTEN is a positive regulator of CMA (Zhang et al., 2023a)] and mice with a liver-specific deletion of CMA receptor LAMP2A show remarkably similar phenotypes, i.e., spontaneous development of fatty liver disease, reductions in peripheral adiposity, and a shift in liver energy production favoring glycolysis over oxidative phosphorylation (Stiles et al., 2004; Schneider et al., 2014).