Pathogenic variants in the LMNA gene cause, among other conditions, autosomal dominant Emery-Dreifuss muscular dystrophy type 2 (EDMD2; MIM 181350), and the Slovenian type hand-heart syndrome (MIM 610140), as well as autosomal recessive Emery-Dreifuss muscular dystrophy type 3 (EDMD3; MIM 616516). This evidence concerns the gene LMNA and Emery-Dreifuss muscular dystrophy 2, autosomal dominant.