IDH1 and glioblastoma: For validation, we reviewed 976 cases from publicly available GB datasets (Figure 1E) and extracted 425 cases that included age, sex, EOR, IDH1 status, MGMTp status, and survival data, which we defined as the “Full dataset.” The Full dataset consisted of 159 cases from TCGA-GBM, 36 cases from CPTAC-GBM, 8 cases from IvyGAP, and 222 cases from UPENN-GBM (Figure 1F).