In a prospective observational study involving 64 volunteers, it was found that the acute phase protein C reaction protein, LPS‐binding protein, serum amyloid A1, and orosomucoid 1 in overweight/obese IBD patients were significantly lower than ordinary IBD patients, and overweight/obesity could further promote the microbial diversity of UC, as indicated by the increased abundance of some probiotics, including P. distasonis, Alistipes indistinctus, and Ruminococcus bromii.115. The gene discussed is ORM1; the disease is irritable bowel syndrome.