Transplantation of P. distasonis ATCC 8503 improved liver histology in mice with hepatic fibrosis and reduced alanine aminotransferase (ALT) and the gene and protein expression of proinflammatory factors and liver fibrosis genes, including IL‐1β, IL6, TIMP1, and TGF‐β.66 This evidence concerns the gene TIMP1 and Hepatic fibrosis.