MPPE1 and melanoma: Our study represents the first depiction of a global immunological landscape in response to anti-PD1 therapy in melanoma patients, deciphering most of circulating immune subsets together (DC subsets [cDC2, pDC, cDC1] and effectors [T, NK, γδT, iNKT cells]), as well as their extended phenotypic and functional features at a protein level.