To decipher the functionality of DC subsets in melanoma patients following anti-PD1 treatment, cytokine production (IL-12p70, IFN-λ1, IFN-α and/or TNF-α) by DC subsets after TLR stimulation was assessed in NR and R patients at several time points (T0, T3/6, T12, T24) by intracellular cytokine staining using multi-parametric flow cytometry (Supplementary Figure 8A). The gene discussed is IFNL1; the disease is melanoma.