During treatment, higher proportions of 41BB+ Tconv cells, LAG3+ γδ2–T and TIGIT+ iNKT cells were observed in R compared to NR patients, while frequencies of GITR-expressing γδ2–T and iNKT, 41BB-expressing NKbright and CD27-expressing NKdim cells were decreased in responder melanoma patients (Supplementary Figure 5G). This evidence concerns the gene TIGIT and melanoma.