The disorder is driven by genetic mutation, mainly to a mutation in either of two genes (RYR2 or CASQ2).1 The mutation results in release of Ca2+ from the sarcoplasmic reticulum (SR) of cardiac muscle due to a sudden catecholamine surge and thus causes ventricular arrhythmias, including ventricular fibrillation (VF), VT, premature ventricular contractions (PVCs), and even atrial arrhythmias. This evidence concerns the gene RYR2 and Ventricular arrhythmia.