Souza et al. (2017) demonstrated the protective effects of exercising on the BBB permeability in an experimental model of autoimmune neuroinflammation. Experimental autoimmune encephalomyelitis (EAE) mouse model subjected to exercise showed decreased BBB permeability and downregulated cytokines expression, such as IFN-γ, IL-6, IL-17, and IL-1b (Souza et al., 2017). IL-6 levels were increased in treadmill-running mice while TNF-α levels were decreased in the hippocampus (Pervaiz and Hoffman-Goetz, 2012). Here, IL6 is linked to experimental autoimmune encephalomyelitis.