The result of the chi-square test indicated that there was no significant difference between the number of cases with the same and different structures of in situ and invasive carcinomas (P=0.484) (Table 2).Among 51 samples of carcinoma in situ, ER.PR value was found negative in 12 samples (23.5%) and positive in 39 samples (76.5%). The gene discussed is ESR1; the disease is invasive carcinoma.