Figure 2 describes the application of sirolimus in mTOR inhibition in the context of G protein-coupled receptor signaling. Previously, sirolimus has been used in multiple mouse models to treat vascular malformation disorders (103, 104). Sirolimus may also minimize the risk of stroke or stroke-like episodes and can potentially better stabilize seizures in mice (105). A clinical trial using topical rapamycin combined with pulsed dye laser (PDL) on the lateral areas of a PWB showed decreased skin pigmentation and a reduced frequency of blood vessels throughout the brain tissue (106). Here, MTOR is linked to Stroke.