SMAD3 and glomerulosclerosis: Among its components, Lei Gong Teng polyglucoside has been shown to alleviate glomerulosclerosis in rats with adriamycin nephropathy by regulating the expression of TGF-β1, Smad3, p-Smad2/3, and Smad7 (Wan et al., 2014) (Figure 2).