Qiu et al. (2024) found that in a cisplatin (CP)-induced AKI mouse model, intervention with gastrodin (GAS) significantly increased the expression of silent mating type information regulation 2 homolog-1 (SIRT1), indicating that GAS alleviates lipid peroxidation and inhibits ferroptosis in CP-induced AKI mice via the SIRT1/FOXO3A/GPX4 signaling pathway. The gene discussed is SIRT1; the disease is acute kidney injury.