The molecular docking was carried out on the active site of human peroxiredoxin 5 (PDB code 1HD2, alpha estrogen receptor alpha (ERα; PDB: 5GS4) and pirin inhibiting target [PDB: 3ACL] for antioxidant study, breast cancer and skin cancer cell lines respectively using Auto dock vina program. The gene discussed is ESR1; the disease is breast carcinoma.