In an animal model of heart failure in pigs, Hinke et al. found that the miR-21 inhibitor antimiR-21 had the most significant effect on miR-21 manipulation and inflammatory response signaling, and miR-21 was significantly suppressed, leading to suppression of inflammatory response and mitogen-activated protein kinase signaling pathways, reduced inflammatory response, and improved heart function (56). This evidence concerns the gene WNK2 and heart failure.