The inclusion criteria were as follows: (1) onset of secondary sexual characteristics in girls before 8 years of age; (2) GnRH stimulation test showing a peak LH level (LHP) ≥ 5 mIU/mL and an LHP/FSHP ratio > 0.6; (3) ovarian volume ≥ 1 mL; (4) exclusion of secondary CPP due to other causes; and (5) no history of drug treatment related to CPP, including Chinese herbal medicines. The gene discussed is PLOD1; the disease is central precocious puberty.