Patients with diabetic kidney disease exhibit an increased risk of osteoporosis attributable to decreased renal 25-hydroxyvitamin D-1α hydroxylase activity, enhanced urinary excretion of vitamin D-binding protein (VDBP) resulted from increased permeability of the glomerular filtration membrane, and imbalance in calcium and phosphorus metabolism in serum and bone (3). Here, GC is linked to diabetic kidney disease.